The actors are in talks to star in the Ed Zwick-directed movie, formerly titled "Pharma," based on Jamie Reidy's nonfiction book "Hard Sell: The Evolution of a Viagra Salesman."
Jake would play a drug rep that starts a romantic relationship with a woman who has Parkinson's disease, played by Anne.
"Love and Other Drugs" is slated to start shooting in the fall.
Anne also has "Alice in Wonderland" coming up in March 2010 and a sequel to "Get Smart," which is scheduled to start shooting in May with Steve Carell. Jake has "Prince of Persia: The Sands of Time" debuting in theaters in May 2010.