Reese Witherspoon Set To 'Rule' The Big Screen

Friday, Oct 30, 2009  |  Updated 11:00 PM EDT
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Reese Witherspoon to "Rule" the Big Screen

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Reese Witherspoon is ready to "Rule" the box office again.

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Reese Witherspoon is ready to "Rule" the box office again.

Reese has signed on to star in and produce "Rule #1," a drama about a New York woman who befriends a Puerto Rican girl with attention deficit disorder, according to The Hollywood Reporter.

VIEW THE PHOTOS: Access' Top 10 Most Anticipated Movies Of 2010

Terrel Seltzer, who co-wrote the George Clooney/Michelle Pfeiffer 1996 romantic comedy "One Fine Day," penned the script for "Rule."

Reese most recently lent her voice to last spring's animated hit "Monsters vs. Aliens," but was last seen on the big screen opposite Vince Vaughn in 2008's "Four Christmases."

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She will next star in a still-untitled James L. Brooks ensemble comedy alongside Paul Rudd, Owen Wilson and Jack Nicholson, which is due in theaters in December 2010.

Related Content from AccessHollywood.com:
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PLAY IT NOW: Reese Witherspoon Talks 'Monsters Vs. Aliens'

MORE ACCESS ON THESE TOPICS: Reese Witherspoon - Movies - Casting Call

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