Police seized 8.8 tons of cocaine along the Colombia-Panama border with an estimated street value of $240 million, Colombia's government said.
Colombia's President Juan Manuel Santos said on Twitter the haul was the "biggest seizure of drugs in history."
Defense Minister Luis Carlos Villegas said the drugs belonged to the Clan Usuga crime gang.
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Colombian authorities seized 278 tons of the narcotic in 2015, NBC News reported.