That's because the hall is all about humans -- and their evolution over 6 million years.
More than 285 early human fossils and artifacts will be on display, including the only Neanderthal skeleton in the United States.
There's also a station that will allow visitors to see what they would look like as early humans. (Cue the Geico caveman jokes.)
Smithsonian Origins Opens
Evolution is one of those topics with a history of controversy, but museum curators say science can be compatible with religious perspectives.
The National Museum of Natural History attracted 7.4 million visitors last year, making it America's most popular museum.