Daniel Coursey scored 17 points and Mercer pulled off the biggest upset in the NCAA tournament so far by knocking off Duke 78-71.
Jakob Gollon added 20 points for the 14th-seeded Bears (27-8).
The Atlantic Sun champions — the same league that produced 2013 tournament darling Florida Gulf Coast — shot 56 percent.
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The Bears were simply too much for a Duke team with stars Jabari Parker and Rodney Hood.
Mercer scored 11 straight points during the late 20-5 run that clinched the biggest victory in school history. It's the second one-and-done in three years for the third-seeded Blue Devils.