Obama will be interviewed by the show's host, John Walsh, on the episode airing 9 p.m. EST Saturday on Fox.
The president will discuss the show's impact in its 22 years as well as his administration's anti-crime initiatives, including those involving white-collar crime, Fox said Wednesday.
Walsh, whose 6-year-old son Adam was abducted and killed in 1981, has been host of "America's Most Wanted" since its start. According to Fox, the show has helped capture more than 1,100 fugitives and reunited 43 missing children with their families.
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