The exhibit, "From FDR to Obama: Presidents on Time,'' opened Friday.
It includes 30 works, ranging from traditional oil paintings to a pop-art sculpture bust of Richard Nixon made from strips of newspaper.
The gallery holds more than 2,000 works of art from Time magazine. Every president since 1923 except for Herbert Hoover has been portrayed on the magazine's cover.
Acting museum director Brandon Fortune says the Time portraits help fuel a discussion that links art, history and biography.
The exhibit is open until September.