Andrew Madoff, Bernard Madoff's last surviving son, died of cancer on Wednesday, his lawyer said.
Andrew Madoff and his brother, Mark, both worked on a trading desk at Bernie Madoff's firm, a side of the business that wasn't directly involved in their father's $65 billion Ponzi scheme.
Bernard Madoff was arrested in December 2008. Almost exactly two years later, Mark Madoff hanged himself by a dog leash on a metal ceiling beam in his Manhattan loft apartment, as his 2-year-old son slept in another room.
"One way to think of this is the scandal and everything that happened killed my brother very quickly," Andrew Madoff told People magazine last year. "And it's killing me slowly."
Andrew Madoff, 48, died at a New York City hospital from mantle cell lymphoma, his attorney Martin Flumenbaum said.
He was first diagnosed with the rare form of cancer in 2003 but went into remission. He blamed the relapse on the stress of living with his father's scam. The disease returned in October 2012 and he told People magazine that he felt "blindsided."
Andrew Madoff had served as the chairman of the Lymphoma Research Foundation's board of directors until his father's scheme was revealed.
Funeral arrangements will be private.