Only Metro's Blue and Orange lines will be affected by track work this weekend.
On the Orange Line, buses will replace trains between Stadium-Armory and Cheverly.
Trains will run every 15 minutes (as opposed to normal 12-minute intervals) in two segments: between New Carrollton and Cheverly, and between Stadium-Armory and Vienna.
The Deanwood and Minnesota Avenue stations will be closed due to platform construction.
On the Blue Line, buses will replace trains between the Stadium-Armory and Benning Road stations.
Trains will run every 15 minutes in two segments: between Franconia-Springfield and Stadium-Armory, and between Largo Town Center and Benning Road.
The changes will be in effect from 10 p.m. Friday to closing time Sunday.
There is no scheduled work on the Red, Green or Yellow lines, which will all operate on regular weekend schedules.