The comedian - who has courted controversy herself on numerous occasions over the course of her career - took to her blog in semi-defense of Sheen.
According to posts quoted by Deadline, Barr claims she and Sheen are not alone.
"Me, Cybil S(hepherd), Brett Butler, Charlie Sheen (stars who lost big when working with Chuck)"
She goes on to claim that the best thing for Sheen to do would be to take a break.
"I fired Chuck Lorre for being a big drunk on my show, and he went on to become one of tv's most successful writers (about dick jokes)."
"I feel sorry for Charlie Sheen, (and Brett and Cybil, both of whom were often out in the parking lot screaming at Chuck and crying) who has to not only be the bi-polar wizard Charlie Sheen, but had to toil as a tool for Lorre Enterprises Inc. and ... Julie Chen's very old comedically incontent husband, Les, the power behind CBS, the network of choice for the dentally challenged."
"Charlie, take a break dude. Go to Greece, Paris, China, look at great art and lay low. You got fired, dude. Anybody can do your job, really. Other guys are funny and not repulsive to intelligent women, though those sh*t Chuck Lorre lines could choke a f**king horse, and render any actor who recites them stone cold soul dead."
Apart from a "vanity card" at the close of a recent "Two and a Half Men" episode, Lorre has remained silent about the Sheen situation and has not said a word about the star's recent firing by Warner Bros.