Travis Trice scored 23 points, and Michigan State knocked second-seeded Virginia out of the NCAA Tournament for the second straight year, 60-54 on Sunday.
Branden Dawson added 15 points and nine rebounds for the seventh-seeded Spartans, who advanced to the Sweet 16 for the seventh time in the last eight seasons under coach Tom Izzo. The Spartans will play the winner of the Oklahoma-Dayton game in Syracuse, New York on Friday.
With top seed Villanova having lost Saturday, it is the first time a No. 1 and 2 seed from the same region didn't advance to the Sweet 16 since Kentucky and Gonzaga in 2004.
The Spartans stole a page from last year's regional semifinal win, limiting the Cavaliers to 29.8 percent shooting. Virginia finished 2 of 17 from 3-point range.
Last year, the Spartans upset the top-seeded Cavaliers in the regional semifinal by holding Virginia to 35.1 percent shooting.
The Cavaliers (30-4) were led by Anthony Gill's 11 points and Darion Atkins' 10 points and 14 rebounds.